The risk of breast cancer associated with brca1 and brca2 gene genetic mutation: A review

Breast cancer is a heterogeneous disease which is caused by the mutation in multiple genes. The discovery of mutations in BReast CAncer susceptibility gene (BRCA1/BRCA2) increases the risk of breast cancer in women. The various factors for breast cancer includes hereditary, environment, lack of breast-feeding and geographical location. Among these factors the early onset BRCA1/2 should be considered more with breast cancer history. The most important role is to detect the mutation carriers earlier in these genes for prevention, diagnosis and better treatment. The present study was aimed to review mutations in two predisposing genes (BRCA1/2). The mutation location and mutation type was summarized and classified for these two genes with some exons are having high mutation. By sequencing these high muted exons reduces the memory, run time, search time and has more accurate sequence data for predicting breast cancer. This study may be useful for selecting and screening the particular exon for patients with breast cancer.