Design and predicted optimized extended release aceclofenac microparticle formulations

Optimization is a process of making a formulation as select as possible within a given physical, chemical and biological consideration. The final product must meet the requirement from a bioavailability, practical mass production and product reproducibility standpoint. Development of Extended release formulation employing optimization technique is based on many statistical experiments which are recognized as useful techniques to design an optimized formulation with desired properties wide. Particle size, entrapment efficiency and dissolution rate. In a short time period and with minimum number of trials. In the present study, two optimized formulations of Aceclofenac, employing different polymers (ethyl cellulose and eudragit RSPO), have been generated through use of software based optimization technique, response surface methodology (RSM). The predicted optimized formulations need validation to find their suitability for acceptance. Validation of predicted optimized aceclofenac formulations.