Indian Journal of Medical & Paediatric Oncology

  • Year: 2005
  • Volume: 26
  • Issue: 3

Testicular germ cell tumour in a young child with down's syndrome

  • Author:
  • K.C. Aggarwal, L. Appaji, B.S Aruna Kumari, H.K. Dadhich, M. Padama, H.S. Mamatha, Rekha Kumar
  • Total Page Count: 2
  • DOI:
  • Page Number: 47 to 48

Pediatric oncology unit, Kidwai memorial institute of oncology, Dr. M.H. Marigowda Road, Bangalore, Karnataka-560 029

*Correspondence to: Hemant Kumar Dadhich E-mail: hkdadhich@yahoo.co.in

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Abstract

Germ cell tumour is an uncommon malignancy in children constituting 1 to 2% of total childhood cancers. Testicular yolk sac tumour with retroperitoneal lymph nodes in a three year old child with Down's syndrome is reported. Such an association with trisomy 21 has been reported infrequently. Diagnosis was confirmed by histopathology and high serum alpha-fetoprotein levels (AFP). Trisomy 21 was confirmed by conventional karyotyping. Patient was treated with high inguinal orchidectomy and six cycles of chemotherapy consisting of carboplatin, etoposide (VP-16) and bleomycin. Regression of tumour was confirmed by normal serum AFP levels and normal ultrasound abdomen.