1Senior Resident, Dept. of Pediatrics, Veer Surendra Sai Institute of Medical Sciences, Odisha
2Associate Professor, Dept. of Pediatrics, Veer Surendra Sai Institute of Medical Sciences, Odisha
3Assistant Professor, Dept. of Biochemistry, IMS & SUM Hospital, Bhubaneswar
*Corresponding Author: Email: drnihar.mishra@gmail.com
Online published on 19 September, 2016.
Peritoneal dialysis (PD) is the main stream of treatment as renal replacement therapy in pediatric patients with AKI in developing countries. Acute kidney injury (AKI) is a well-recognized complication of severe malaria in adults, but its incidence, prevalence and clinical importance in paediatric medicine not well documented.
To find out the effect of peritoneal dialysis on outcome of malarial AKI children in a tertiary care centre.
A cross-sectional study done in under 14 children suffering from severe malaria (SM). Neonates, children with associated pre-existing renal disease or having chronic kidney disease (CKD) or acute on CKD and known hypertensives were excluded. All the enrolled children were screen for AKI as per KDIGO guidelines & categorised in two three stages. PD was done as per the predefined criteria& all relevant data were analysed with computer generated software.
Out of 406 SM cases, AKI detected in 15% with female predominance Mortality among renal failure patients is 26.67%. PD required in 52.0% of patients & mortality rate of 25.0% in KDIGO stage I, II but 55.0% in KDIGO Stage III significance(p=0.000). There is a significant correlation between pre dialysis & post dialysis serum urea/creatinine/potassium/TPC & urine output (p = 0.000).
AKI is an under-recognized complication in young kids with SM and is related to enhanced acute/long-term morbidity & mortality. Its early detection & intervention by peritoneal dialysis improves the same.
Severe malaria (SM), Acute Kidney Injury (AKI), Peritoneal dialysis(PD), KDIGO(Kidney DiseaseImproving Global Outcome) guidelines, Chronic, Kidney Disease(CKD)
