Bacteriological profile and antimicrobial susceptibility patterns of organisms responsible for blood stream infections

Blood stream infections (BSI) are an important cause of morbidity and mortality. An assessment of a patient with BSI includes routinely a blood culture. Blood cultures provide us information on the causative organism and their antibiotic susceptibility over the past few decades.

To identify organisms responsible for Blood stream infections, study their bacteriological profile and antimicrobial susceptibility patterns.

This study was undertaken to analyze all blood culture reports from January 2015-July 2015 at a tertiary care hospital in Hyderabad, India. A total of 485 blood culture reports were analyzed all suspected cases of septicemia.

Best sensitivity of the gram positive isolates were for vancomycin and Tigecycline, both giving 97.67% sensitivity followed by Linezolid at 91.86%. The isolates showed good sensitivity of 77.91% to Teicoplanin and Beta-Lactamase combination showing a sensitivity of 72.09% to cefoperazone sulbactam, 66.28% to Ampicillin-sulbactam and 73.26% to cefepime-tazobactum. Resistance was high to other Beta-lactam antibiotics and the Macrolides.

The study showed a predominance of gram positive organisms as compared to gram negative isolates, most of the isolates were resistant to multiple antibiotics.