1Assistant Professor, KD Medical College, Hospital & Research Center, Mathura, Uttar Pradesh
2Professor & Head, Dept. of Microbiology, SBKS Medical Institute & Research Centre, Vadodara, Gujarat
To isolate and characterize the Candida species from various clinical samples. To determine the spectrum of Candidiasis. To determine the predisposing factors for Candidiasis.
This Prospective Analytical study was conducted in the Department of Microbiology of a Teaching Tertiary care Rural hospital of Western India over a period of 1½ years after obtaining Ethical clearance. A total of 1438 samples submitted to department of microbiology for routine diagnostic work up were assessed. A detailed review of history & clinical findings was undertaken. Fifty isolates which fulfilled the diagnostic criteria for Candidiasis were selected, included in the study and subjected to a battery of microbiological investigations aimed at detecting, isolating, identifying and characterizing Candida sp.so as to determine the spectrum of Candidiasis.
The incidence rate of Candidiasis in clinical specimens came out to be 35 per thousand samples per year. The species wise distribution of Candida isolates was C.albicans(42%), C.tropicalis(50%), C.glabrata(4%), C.parapsilosis(2%) & C.krusei(2%).
Results indicate a significant shift in the species causing invasive Candidiasis away from C.albicans to more resistant Non-albicans species which has important clinical implications.
Candidiasis, Characterisation, Shift, Non-albicans sp, Germ tube test, Chlamydospore, Sugar assimilation test
