1Tutor, Dept. of Microbiology, Shivamogga Institute of Medical Sciences, Shivamogga, Karnataka
2Professor & HOD, Dept. of Microbiology, Shivamogga Institute of Medical Sciences, Shivamogga, Karnataka
3Post Graduate, Dept. of Microbiology, Shivamogga Institute of Medical Sciences, Shivamogga, Karnataka
4Assistant Professor, Dept. of Microbiology, Shivamogga Institute of Medical Sciences, Shivamogga, Karnataka
*Corresponding Author: Email: trsganeshjai@gmail.com
Online published on 20 June, 2017.
Streptococcus pyogenes producing quinolone resistance are an increasing cause of concern in the hospitals as they produce a therapeutic dilemma for the treating physician. The present study was undertaken to know the prevalence of quinolone resistant streptococcus pyogenes from clinical isolates and their antibiotic resistance pattern.
A total of 28 streptococcus pyogenes were recovered from various clinical specimens. All the samples were processed for routine bacterial culture and antimicrobial susceptibility test as per standard protocol (CLSI, Koeneman's Text Book).
Of 28 streptococcus pyogenes isolates 8(34.78%) were showing Quinolone resistance. In this study, we investigated antimicrobial activity of 20 widely used antibiotics against S. pyogenesisolates. Tetracycline (53.57%), Ampicilin (32.14%), Erythromycin (32.14%) Cotrimoxazole (39.28%), Levofloxacin (28.57%) and Ciprofloxacin (28.57%) were resistant. Cephalosporins like Ceftazidime (21.42%), Cefotaxime (21.42%) and Azithromycin (21.42%) were less resistant. Cefepime (10.71%), Linezolid (7.14%) and Vancomycin (3.57%) were least resistant. All the isolates were sensitive to Meropenem. Majority of Quinolone resistance isolates were resistant to tetracycline.
Of 28 streptococcus pyogenes isolates 8(34.78%) were showing Quinolone resistance. Cefepime (10.71%), Linezolid (7.14%) and Vancomycin (3.57%) were least resistant. All the isolates were sensitive to Meropenem
Streptococcus Pyogenes. Quinolone resistance, GAS Infection, Therapeutic options
