Antibiotic profile of pseudomonas aeruginosa strains isolated in a teritiary care centre

Multidrug resistance among clinical samples has emerged as a major problem in clinical settings. Pseudomonas aeruginosa is an opportunistic, nosocomial pathogen inherently resistant to many drugs and is able to acquire resistance to all effective antimicrobial drugs. Multidrug-resistant (MDR) P. aeruginosa is an emerging cause of mortality and morbidity which causes 4–60% nosocomial infections worldwide.

The aim of the present study was to determine the antimicrobial susceptibility pattern of P. aeruginosa isolates from various clinical samples in a tertiary care centre.

100 Pseudomonas aeruginosa isolates from various clinical samples, collected in a tertiary care hospital over a period of 6 months were included in the study. Antimicrobial susceptibility testing was performed using Kirby-Bauer disc diffusion method. Interpretation was done according to the CLSI guidelines. Quality control was performed by using a standard strain of Pseudomonas aeruginosa ATCC 27853.

Among the entire gram negative organism isolated from different samples Pseudomonas aeruginosa isolates were around 29%. Out of the 100 Pseudomonas aeruginosa isolates studied, 87% were sensitive to Imipenem, 69% to Amikacin, 82% to Piperacillin-Tazobactum, 69% to Aztreonam, 31% to third generation cephalosporins, 34% to Gentamicin & 47% to Ciprofloxacin respectively

In order to control antimicrobial resistance and to keep it in check it is necessary to practice effective antibiotic policies, frequent surveillance programs and adequate infection control measures.