International Journal of Medical Research & Health Sciences
  • Year: 2013
  • Volume: 2
  • Issue: 2

Detection of inducible clindamycin resistance among clinical isolates of staphylococci from a rural tertiary care hospital

  • Author:
  • Makam Sri Rangakumar Manjunath1, Vijaya Rayapu2, Dhandapany Senthil Pragash2,, Ivvala Anand Shaker3, Sandeep Kasukurthy4
  • Total Page Count: 7
  • Page Number: 182 to 188

1Technician “C’’ National Institute of Virology, Bangalore, India

2Department of Microbiology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur, 603319, India

3Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur, 603319, India

4Research Assistant, RMRC (ICMR), Port Blair, Andaman & Nicobar Island, India

*Corresponding author Email: drsenthiledu@gmail.com

Abstract

Clindamycin has been used successfully to treat pneumonia and soft tissue infections caused by methicillinresistant Staphylococcus aureus. However, Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to Macrolide, Lincosamine and Streptogramin antibiotics.

A total of 96 staphylococcal isolates from different clinical specimens were tested for inducible clindamycin resistance by the diskdiffusion induction test using erythromycin (15μg) disk and clindamycin (2μg) disc placed 15mm (edge to edge).

Inducible clindamycin resistance was detected in 47.22% of methicillin-resistant Staphylococcus aureus isolates and in 21.67% of methicillinsensitive Staphylococcus aureus isolates. In our setting, clindamycin is safe and effective agent to treat both systemic sand localized Staphylococcal infections, but we recommend that staphylococci isolates, particularly methicillin-resistant Staphylococcus aureus, are tested by the Dtest routinely to avoid treatment failure.

Keywords

Inducible clindamycin resistance, Methicillin resistant Staphylococcus aureus, D test