1Asst. Professor, Department of Biochemistry, BLDEU's Shri B M Patil Medical College, Bijapur, Karnataka
2Lecturer, Department of Pharmacology, BLDEU's Shri B M Patil Medical College, Bijapur, Karnataka
*Corresponding author Email: nagarajshetkar@gmail.com
Emphysema is associated with high incidence of morbidity and mortality. The imbalance between oxidants and antioxidants is thought to play an important role in the pathogenesis of Emphysema.
A total number of 80 subjects comprising of 40 healthy controls and 40 Emphysema cases were studied. In all the subjects, serum levels of malondialdehyde (MDA) as a biomarker of lipid peroxidation and antioxidant whole blood reduced glutathione (GSH) were estimated.
The level of whole blood reduced glutathione was significantly decreased in emphysema patients when compared to controls. Serum MDA was significantly increased in Emphysema patients when compared to controls.
The presence of increased systemic oxidative stress in emphysema patients seems to be associated with current active smoking and systemic inflammation. The decrease in antioxidants levels appears to be mainly a consequence of increased oxidative stress. This suggests that oxidative stress is likely to be involved in pathogenesis of emphysema.
Oxidative stress, Antioxidants, Emphysema, Whole blood reduced glutathione, MDA
