International Journal of Medical Research & Health Sciences
  • Year: 2014
  • Volume: 3
  • Issue: 4

Comparative evaluation of Azelastine and Fluorometholone in the treatment of spring catarrh (vernal catarrh)

1Professor, Department of Ophthalmology, Gandhi Medical College, Hyderabad

2Assistant Professor, Department of Pharmacology, Osmania Medical College, Hyderabad

*Corresponding author email: ather11258@gmail.com

Online published on 20 October, 2014.

Abstract

To study and compare the efficacy of FML & Azelastin eye drops in relieving symptoms & regressing signs of VKC.

This Prospective Interventional study conducted at Sarojini Devi eye hospital, Hyderabad which is a regional institute of Ophthalmology during the period July 2004 to July 2005. The 100 patients of spring catarrh reported to SD eye hospital during the period were randomly divided into 2 groups of 50 each. Group I were given Fluorometholone 0.25% eye drops four times daily for a period of 4 weeks. Group II were given Azelastine HCI 0.05% eye drops four times daily for a period of 4 weeks.

Documented by taking symptomatic relief of patient, Clinical improvement of signs, reduction in Eosinophils and Mast cells on histopathological examination.

This study shows that Fluorometholone is superior to Azelastine in relieving Symptoms and regression of signs in the cases of Vernal catarrh.

Keywords

Vernalkeratoconjunctivitis (VKC), FML (Fluorometholone), Azelastine, Eosinophils, Mast cells