1Department of Dermatology, Velammal Medical College, Madurai, Tamilnadu, India
2Department of Physiology, Sri Venkateswara Medical College, Tirupathi, Andhra Pradesh, India
3Department of Dermatology, Shanthiram Medical College, Nandyal, Andhra Pradesh, India
44Department of Physiology, Narayana Medical College, Nellore, Andhra Pradesh, India
*Corresponding author: Desireddy Neelima, Department of Dermatology, Velammal Medical College, Madurai, Tamilnadu, India, Email: neelimadermatlogist@gmail.com
Online published on 27 October, 2015.
Pellagra was vanished from most parts of the world where it was formerly present due to its dietary modification. However, it is still encountered among the jowar eating populations of India. The information about the role of oxidative stress in pellagra was not established. Therefore, in this study we assessed the oxidative stress status by using malondialdehyde (MDA), total anti oxidant status (TAOS) and redox ratio (RER) in clinically diagnosed pellagra patients.
Clinically diagnosed pellagra patients aged between 18 to 40 years, both male and females were recruited (n=78) from department of Dermatology. Age and gender matched controls (n=78) were recruited from the student and residents of the hospital. Malondialdehyde (MDA) is a marker of lipid peroxidation, Total Anti Oxidant Status (TAOS) and Redox Ratio (RER) markers were assessed by using commercially available kits.
There were no significant differences in the anthropometric parameters. However, the oxidative stress markers MDA (p<0.05), RER (p<0.001) were significantly high and TAOS was low (P<0.001) in pellagra patients in comparison with age and gender matched controls.
The results of this study showed the increased MDA, RER levels and decreased TAOS levels. Estimation of these markers at early stage will help to take measures to prevent the progression of disease and develop antioxidant strategies.
Total anti oxidant status, Malondialdehyde, Redox ratio, Pellagra
