International Journal of Medical Research & Health Sciences
  • Year: 2016
  • Volume: 5
  • Issue: 8

Relationship between selenium and prostate cancer risk; systematic review and meta-analysis and meta-regression

  • Author:
  • Yadolah Fakhri1, Parviz Kokhaei8, Mahboobeh Moradi2, Maryam Dadar3, Nazak Amanidaz4, Yahya Zandsalimi5, Bigard Moradi6, Leila Rasouli Amirhajeloo7, Hassan Keramati8,
  • Total Page Count: 12
  • Page Number: 44 to 55

1Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

2Studends Research Office, Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

4Environmental Health Research Center, Golestan University of Medical Sciences, Golestan, Iran

5Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

6Department of Health Public, Kermanshah University of Medical Sciences, Kermanshah, Iran

7Department of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran

8Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran

*Corresponding Email: Hkramatee@gmail.com

Online published on 29 September, 2018.

Abstract

Prostate cancer is one of the five most common cancers in men. It is suspected that selenium protect or exacerbate the risk of prostate cancer. The aim of this study was to determine the association between prostate cancer risk and selenium in the serum, toenail and supplements. So it was tried to do a systematic review and meta-analysis and meta-regression of 22 studies (5 toenail studies, 14 serum studies and 3 supplements studies) in order to obtain detailed results of these studies’ data. Meta-regression results showed that location of study (p value <0.001), type of study (p value = 0.04) and age (p value =0.008) have significant effects on heterogeneity. There was no publication bias in studies (Begger's test: z-value = 1.98; P value=0.067). In general, unlike selenium supplements [OR=0.86 (CI: 0.7–1.06, P value=0.15], selenium increase in serum [OR=0.76 (0.59–0.99, P value=0.04] and toenail [OR=0.58 (0.4–0.86, P value=0.01] significantly decreased the risk of prostate cancer by %24 and 42%. In general, the odds ratio between prostate cancer caused by selenium in the random effect model OR: 0.71 (CI: 0.590.86%, P value <0.001) and heterogeneity was moderate (I2 = 70.6%, P value <0.001). The results of this study supported the lowering effect of selenium in serum and toenail on the risk of prostate cancer.

Keywords

Selenium, Prostate Cancer, Serum, Toenail, Supplements, Meta-analysis and Meta-regression