1Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Environmental and Food Hygiene Laboratories (LIAA), ‘G.F. Ingrassia’ Department Hygiene and Public Health, University of Catania, Catania, Italy
3Department of environmental Health Engineering, School of Public Health, Semnan University of Medical Sciences, Semnan, Iran
4Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
5Department of Health Public, Kermanshah University of Medical Sciences, Kermanshah, Iran
6Department of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran
7Student research office, Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical sciences, Tehran, Iran
8Environmental Health Research Center, Golstan University of Medical Sciences, Golstan, Iran
*Corresponding Email: abotaleb_bay@yahoo.com
Online published on 29 September, 2018.
Prevalence of diabetes, especially type 2 diabetes is increasing. One of the environmental risk factors of this disease is persistent organic pollutants. Studies have obtained different results in the field of association of different congeners of persistent organic pollutants such as polychlorinated biphenyls with type 2 diabetes. In this review study (systematic review and meta-analysis), the authors aimed to evaluate the association of different congeners of polychlorinated biphenyls with type 2 diabetes in both prospective and cross-sectional studies. After a systematic review, 6 prospective and 9 cross-sectional studies were evaluated. Mean of odds ratio and heterogeneity for all the studies were OR=1.97; CI (1.57–2.39) and I 2 =42.9%; ρheterogeneity=0.009, respectively. Also, mean of odds ratio for the prospective studies (OR=1.59; CI(1.29–1.95); I 2 =2.37%; ρheterogeneity=0.42) was less than that of the crosssectional studies (OR=2.4; CI (1.71–3.36); I 2 =49.8%; ρheterogeneity= 0.025). Increase in different congeners of PCBs in the serum and adipose tissue can significantly increase the prevalence type 2 diabetes (p value<0.001). This study supports a positive association of polychlorinated biphenyls in the serum and adipose tissue with type 2 diabetes.
Polychlorinated biphenyls, Diabetes, systematic review, meta-analysis, serum, adipose tissue
