1Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Environmental and Food Hygiene Laboratories (LIAA), ‘G.F. Ingrassia’ Department, Hygiene and Public Health, University of Catania, Catania, Italy
3Studends Research Office, Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Environmental Health Research Center, Golstan University of Medical Sciences, Golstan, Iran
5Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
6Department of Health Public, Kermanshah University of Medical Sciences, Kermanshah, Iran
7Department of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran
8Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
*Corresponding Email: Hkramatee@gmail.com
Online published on 29 September, 2018.
The prevalence of metabolic disease type 2 diabetes is increasing. Numerous studies have to take into consideration in addition to the factors such as low mobility, nutrition and inheritance, environmental factors such as hexachlorobenzene in creation of type 2 diabetes. Therefore, it was tried in this study to obtain an exact result regarding the association of hexachlorobenzene with type 2 diabetes by doing a systematic review and metaanalysis of the cross-sectional and prospective studies which were received till 2 March 2016. After searching in the databases SID, Irandoc, Pubmed, Scopus, Ovid, Embase, ISI and Cochrane, 10 studies with 19 subgroups were considered in final assessment. Geometric mean concentration of Hexachlorobenzene was 12.7 ng/ml and 64.77 ng/g lipids in serum and adipose tissues, respectively. The heterogeneity index of I 2:25.95% (I 2 <50%) and t 2:0.075 were low and hence fixed model was used for meta-analysis of studies’ results. The Pearson correlation coefficient between concentrations of hexachlorobenzene in serum and adipose tissue with the odds ratio of type 2 diabetes were R 2:0.27, P value=0.57 and R 2:0.25, P value=0.18, respectively. The highest and lowest odds ratios of type 2 diabetes was [OR:6.2 (0.6–68.1)] and [OR:0.99 (0.3–2.6)], respectively. Overall, the odds ratio for type 2 diabetes induced to hexachlorobenzene was OR:2.33 (1.82–2.74) P value<0.001. Results of this study supported the role of hexachlorobenzene significantly as an environmental risk factor in type 2 diabetes (P<0.001).
Type 2 diabetes, hexachlorobenzene, serum tissue, adipose tissue, systematic review
