1Hemorheology Center, Chengde Medical College, Chengde, Hebei Province, China
2Hemorheology Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
3Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
4Department of Cardiology, Tokyo Women`s Medical University, Tokyo, Japan
5Non-profit Organization, Chiba Researchers Network for Health Care Promotion, Chiba, Japan
*Corresponding e-mail: nobuo@faculty.chiba-u.jp
Online published on 19 November, 2018.
Hyperuricemia causes gout syndrome, which can manifest as hemorheological damage. However, hemorheological properties have not been well characterized in asymptomatic conditions.
The present study was aimed to investigate the hemorheological changes in rats with asymptomatic hyperuricemia.
The rat model was established by intraperitoneal injection of 250 mg/(kg·d) oxonate acid for 8 weeks. In one group of rats, 70 mg/(kg·d) allopurinol was also administrated for the latter 4 weeks. Control rats were administered CMC-Na solution and water.
Hyperuricemic rats had higher blood viscosity than control rats did. Moreover, their erythrocytes had reduced deformation index, orientation index, surface charges, and osmotic fragility. Treatment with allopurinol decreased the blood uric acid amounts and improved the hemorheological parameters.
Our study suggests that there is deterioration in the hemorheology of hyperuricemic rats and that allopurinol can play a protective role on the deterioration. Therefore, hemorheology can be used as a diagnostic tool in asymptomatic hyperuricemia.
Hyperuricemia, Hemorheology, Blood viscosity, Erythrocyte
