Updates on the Conflict of Postoperative Radiotherapy Impact on Survival of Young Women with Cancer Breast: A Retrospective Cohort Study

The purpose of the present study is to investigate the impact of postoperative radiotherapy on the survival of young women aged 25–29 years diagnosed with different stages of breast cancer.

We conducted a retrospective cohort study that included young women diagnosed with breast cancer from SEER database. The total analytical sample of the present study (n=4153) was divided into two separate groups; intervention group (n=1814) who did receive postoperative radiation therapy (PORT) and control group (n=2339) who did not receive PORT. Chi square test and Kaplan Meier method had been carried out for statistical analysis.

Relative survival rate of the intervention group, estimated by Kaplan-Meier method was found to be (62.9%, CI 95%) for breast cancer stage I, (66.1%, CI 95%) and (58.2%, CI 95%) for stages IIA, and IIB respectively. (30.9%, CI 95%) (54%, CI 95%) and (32.1%, CI 95%) for breast cancer stages IIIA, IIIB, and IIIC respectively and (10.3%, CI 95%) for breast cancer stage IV.

Postoperative adjuvant radiotherapy shows a significant positive impact on overall survival of young women diagnosed with breast cancer stages III, and IV (P<0.05). Moreover, no significant impact on survival was noted for breast cancer stages I, and II.