International Journal of Medical Research & Health Sciences
  • Year: 2018
  • Volume: 7
  • Issue: 5

Estimation of Serum Matrix Metalloproteinases-1 Levels in Iraqi Female Patients with Osteoarthritis

  • Author:
  • Vean Sabah Ali, Zainab A. Aldaher, Sahar H. Abdul-Kareem, Heba F. Hassan, Rasha M. Shaker, Rasha A. Azeez
  • Total Page Count: 5
  • Page Number: 18 to 22

Department of Basic Science, College of Dentistry, University of Baghdad, Baghdad, Iraq

*Corresponding e-mail: sahiarhashim1@yahoo.com

Online published on 19 November, 2018.

Abstract

This study was established to investigate the correlation between the expression of matrix metalloproteinases (MMP-1) and the pathogenesis of osteoarthritis (OA). Blood samples were collected from 55 female patients with inflammatory OA and controls for estimation of serum (MMP-1) levels. In the current study, there is significant increase (p <0.001) in the mean of serum MMP-1 levels in osteoarthritis females (4027.73 ± 1345.28 pg/ml) than that in control females (798.76 ± 136.79 pg/ml). It was concluded that MMP-1 may be associated with the pathogenesis of osteoarthritis.

Keywords

Osteoarthritis, Matrix metalloproteinases, Matrix metalloproteinases-1, Calcium, Alkaline phosphatase, Phosphorus