Evaluation of efficacy, safety and cost effectiveness of oral iron and injectable iron sucrose and ferric carboxy maltose in pregnant women in 2nd and 3rd trimester in anaemia

To compare the efficacy safety and cost effective of oral iron and injectable iron sucrose and FCM in pregnancy in 2nd and 3rd trimester.

A prospective randomised control trial study in 300 women with HB 7-9gm% done in department of obstetrics on Gynae in Muzaffarnagar Medical College, Muzaffarnagar.

Mean changes in Hb: oral iron 9.14gm%, inj.iron sucrose 10.54gm%, inj FCM 11.66gm%. The value of p is < 0.00001. The result is significant at p ≤0.05. Mean changes in PCV: oral iron 25.1%, inj iron sucrose 36.7%, inj FCM 37.46%. The value of p is <0.00001. The result is significant at p ≤ 0.05. Mean changes in MCV: oral iron 74.5Fl. The value of p is 0.172115. The result is not significant at p ≤ 0.05., inj iron sucrose 72.52.4Fl, inj FCM 80.4Fl. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Mean changes in MCHC: oral iron 32.9%, inj iron sucrose 37.6%, inj FCM39.31%. The value of p is < 0.00001. The result is significant at p ≤ 0.05 Mean changes in serum feritin oral iron 28.95 μg/l, inj iron sucrose 29.25 μg/l, inj FCM 47.3μg/l. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Mean changes in serum iron oral iron 36.27μg/dL, inj iron sucrose 38.1 μg/dL, inj FCM 73.8 μg/dL. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Mean decrease in TIBC: oral iron 369μg/dL, inj iron sucrose 330μg/dL, inj FCM 324 μg/dL. The value of p is < 0.00001. The result is significant at p ≤ 0.05. Regarding efficacy both oral iron and injectable group was statistically significant. The value of p is < 0.00001. The result is significant at p ≤ 0.05.

We can conclude from this study that injection FCM is a promising alternative for IDA as its compliance is better than others, it can be safely used for correction of anaemia without any side effects over the mother and fetus.