Successful controlled ovarian stimulation and pregnancy in a woman with hypogonadotropic hypogonadism resulting from transsphenoidal excision of a pituitary macroadenoma

To report pregnancy in women with partial hypopituitarism as a result of surgery for a non-functioning pituitary macroadenoma using recombinant Follicle Stimulation Hormone (rFSH) and Recombinant Luteinizing Hormone (rLH).

A 29-year-old woman with partial hypopituitarism underwent Controlled Ovarian Hyperstimulation (COH) with rFSH, rLH achieving a pregnancy. Co-treatment with rLH enhanced FSH action, promoted follicle development and shortened COH duration and reduced FSH doses.

Ovulation induction in women with partial hypopituitarism requires both Follicle Stimulation Hormone (FSH) and Luteinizing Hormone (LH) to achieve optimal follicular growth. Adding LH from start of stimulation optimizes controlled ovarian stimulation in hypogonadotropic hypogonadism supporting the concept that LH is required in the early follicular phase as well.