Evaluation of efficiency of Sublingual misoprostal and vaginal misoprostal administration for induction of labour

To determine the efficacy and safety of misoprostol administered sublingually and vaginally for induction of labour.

A randomized control trial was conducted on antenatal women for 18 month period from 1st Jan 2015 30th June 2016 admitted to Obstetrics & Gynaecology department of Era's Lucknow Medical College and Hospital Lucknow. Total 120 antenatal women of 37 weeks or more gestational age fulfilling the inclusion criteria were enrolled in the study and they were randomly divided in to two groups (60 women in each group) sublingual group where they received 25 microgram misoprostol sub lingual and vaginal group where25 microgram of misoprostol was administered per vaginally. Same dose was repeated every four hour until 3 or more uterine contraction of 40sec duration occur over 10 minutes, or when a maximum of six doses i, e 150 microgram was reached and labour outcome was noted.

In our study the mean induction-delivery interval in sub lingual group was 13.28 hour and12.96 hour in vaginal group. The rate of caesarean section in the sublingual group was31.7% and invaginal group it was found to be 20%. However, it was not statistically significant. No significant side effect of misoprostol was seen during the study.

Sublingual route of misoprostol administration is as efficacious and safe as vaginal route for induction of labour.