A case of corpus callosum agenesis presenting with recurrent brief depression

Agenesis of Corpus callosum can have various neuropsychiatric manifestations.

Following case report highlights a young a man presenting with features of recurrent brief depressive disorder each lasting for about three to seven days for over a year. He had history of occasional headache and episodes of swooning attack in between usually precipitated by emotional events. His neuroimaging revealed the agenesis of corpus callosum. He was experiencing swooning attacks as he got aware that some ‘unusual’ findings were present in his reports.

Recurrent brief depression can be a manifestation of this congenital anomaly and Conversion disorder can be present as comorbid diagnosis perhaps due to ignorance and fear for this apparently innocuous congenital malformation.