A Study on the Gender Difference in the Induction of Duodenal Ulcer by Cysteamine Hydrochloride in Mice

Duodenal ulcers were induced in adult male and female mice using cysteamine hydrochloride under various experimental conditions. Under these experimental conditions, orchidectomized adult mice strikingly decreased sensitivity to ulcer induction but orchidectomized mice and testosterone propionate administration to orchidectomized adult mice shows increased sensitivity to ulcer induction. This change in ulcer sensitivity reflected from histological, histochemical and biochemical studies. The result showed that ulcer severity was more in ovariectomyzed - cysteamine treated mice than normal male and orchidectomized and treated mice. The histological studies showed that orchidectomy decreased or did not show any change in the ulcer sensitivity considering Cryptus Lieburkuhn and Brunner's glands, but reverse was found in ovariectomyzed and cysteamine treated mice. The same result reflected by differential intensity in the staining property of the Brunner's gland. The biochemical study also showed the same trend in ulcer induction. These findings prove that estrogen and testosterone of booth exogenous and endogenous augment the ulcer pathogenesis in cysteamine induced ulcer but estrogen it is more protective than testosterone.