1Ex Senior Research Fellow, Department of Physiology, Maulana Azad Medical College, New Delhi
2Professor, Department of Pathology, G B Pant Hospital, New Delhi
3Professor, Department of Physiology, Maulana Azad Medical College, New Delhi
Online published on 4 April, 2014.
In the present study, the potential of tempol has been examined as a neuroprotective agent against the toxicity of the 6-hydroxydopamine (6-OHDA) in aged rat. Literature is silent about it. Sprague-Dawley rats were pretreated with tempol and subsequently administered the neurotoxin 6-OHDA into the aged rat striatum. Various behavior and immunohistochemical tests were used to evaluate the neuroprotective effect of tempol. Significant difference in various groups was found (ANOVA, p<0.001) in apomorphine-induced rotational behavior, staircase test success rate & disengage time and (ANOVA, p<0.05) in stepping test, initiation time & postural balance test. On the basis of immunohistochemical changes, the present study concludes that tempol is an effective neuroprotective agent for dopaminergic neurons in 6-OHDA induced aged rat model of Parkinson's disease (PD). Aged rats showed less neuroprotection in dopaminergic neurons loss than young rats
Tempol, 6-Hydroxydopamine, Aged Rat
