1Physiology Department, Faculty of Medicine, Zagazig University, Egypt
2Physiology Department, Faculty of Medicine, Minia University, Egypt
3Physiology Department, Faculty of Medicine, Thamar University, Yemen
Visfatin is an adipokine secreted by adipose tissue. Visfatin has been reported to be involved in several biological processes in the cardiovascular system. However, the effect of visfatin on blood pressure is still unclear. In this study, we examined the effect of visfatin on DOCAsalt hypertensive rats and normotensive control rats.
48 rats were randomized into eight groups (n=6, each), 1- control group. 2- Visfatin treated group 3- Uninephrectomized(UNX) group. 4- UNX plus visfatin treated group. 5- DOCA-salt group. 6- DOCA-salt plus visfatin (1nM) treated group 7- DOCA-salt plus visfatin (10nM) treated group and 8- DOCA-salt plus visfatin (100nM) treated group. Systolic and diastolic blood pressures were recorded every week during the entire period of the study by tail-cuff method.
Visfatin (1nM) produced insignificant inhibitory effect on blood pressure; on the other hand, visfatin (10nM) produced significant and (100nM) highly significant inhibitory effect on systolic and diastolic blood pressures in DOCA- salt hypertensive rats.
The results of the present study demonstrated that visfatin has significant inhibitory effect on the elevated blood pressure in DOCA-salt hypertensive rats. Further studies needed to clarify the detailed mechanisms by which visfatin decreases the blood pressure.
Visfatin, Hypertension, hypertensive Rats, Metabolic Syndrome
