A Comparative Study of Lipid Profile in Smokers and Non Smokers in Bareilly Region

Smoking is one of the environmental factors which can alter normal lipid profile. It is one of the major risk factors in the genesis of coronary atherosclerosis and development of coronary heart disease.

To comparatively evaluate the lipid profile alteration in smokers (>5 years smoking) and non smokers.

The study was conducted on 672 randomly selected apparently healthy male subjects of age group 20-60yrs, of these 336 were smokers and 336 nonsmokers. The subjects selection criteria was on the basis of voluntary participation The subjects were asked to fast overnight, and early morning blood samples collected and analyzed for lipid profile by appropriate standard methods. The student's unpaired "t" test was used for statistical analysis. P-value of (< 0.05) was considered statistically significant.

It was noted that mean S.TC (202.83 ± 25.63 mg/dl),and LDL-C (120.59 ± 29..91 mg/dl), were significantly higher in smokers (p <0.05) as compared to non-smokers, i.e., mean S.TC 196.91 ± 21.71mg/dl), LDL-C (111.01± 31.91). Mean serum TG levels in smokers were also significantly high, i.e., 153.71 ± 21.1 mg/dl (p <0.001) as compared to non-smokers with mean serum TG levels (148.19 ± 22.28 mg/dl). Mean serum HDLC(37.42 ± 10.41 mg/dl) was significantly lower in chronic smokers (p <0.05) as compared to non-smokers, i.e., 38.82 ±7.95 mg/dl.

Smoking causes alterations in lipid profile. Serum total cholesterol, triglyceride, LDL-C were significantly increased, while serum of HDL-C was low in smokers in comparison to nonsmokers. This alteration in serum lipid levels increases risk of coronary artery disease.