1Associate Professor, Department of Physiology, IGIMS, Patna
2Assistant Professor, Department of Physiology, IGIMS, Patna
3Assistant Professor, Department of Biochemestry, IGIMS, Patna
4Professor & H.O.D, Department of Physiology, IGIMS, Patna
*Corresponding author: Tarun Kumar, Associate Professor, Deptt. Of Physiology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna - 800014, Contact no. 9546995057, E mail: omtarun_2005@yahoo.com
Online published on 21 February, 2015.
The study was conducted to assess the role of vitamin D in obesity and Type II diabetes mellitus among elderly males.
The participants were 120 elderly males from the age group of 40 to 60 years divided into two groups on the basis of their Body Mass Index (BMI). Sixty Subjects having BMI < 25 kg/m2 were kept in control group for comparison and remaining sixty subjects having BMI>25 kg/m2 were overweight/obese included in another group under study. Fasting blood glucose level was determined by using commercially available kits and 75 grams Oral Glucose Tolerance (OGT) test was performed. Body fat content was calculated by body fat analyzer and serum level of vitamin D was measured by immunoassay kits.
The results showed that fasting plasma glucose level was >115mg/dl and plasma glucose level after 120 minutes (OGT test) was >200mg/dl among 35% of the participants having BMI>25kg/m2. Serum vitamin D level was less (35 - 65nmol/liter) and Insulin sensitivity index was also decreased (r=0.78, p<0.01) among overweight/obese subjects.
The study suggests that vitamin D deficiency plays very important role in development of insulin resistance leading to obesity and diabetes mellitus type II.
Vitamin D deficiency, Body Mass Index, Oral Glucose Tolerance Test, Diabetes Mellitus type II, Obesity
