1Assistant Professor, Department of Physiology, Venkateshwara Institute of Medical Sciences, Rajabpur, Gajraula, Amroha, U.P.
2Assistant Professor, Department of Microbiology, Venkateshwara Institute of Medical Sciences, Rajabpur, Gajraula, Amroha, U.P.
3Ph.D. Scholar (Medical Biochemistry), Department of Biochemistry, Santosh Medical College, Ghaziabad, U.P.
Online published on 19 June, 2015.
Disturbance of electrolyte balance along with metabolic derangement in diabetes mellitus may results in further development of future hypertension, cardiovascular diseases, osteopenia, renal failure and many other complications. Estimation of urinary Na+, K+ & Ca++ can be useful marker for diabetes mellitus as well as may be helpful in preventing other fatal diseases like hypertension, Chronic renal failure etc in diabetic patients.
Newly diagnosed 37 patients with Type 2 diabetes mellitus compared with 30 age & sex matched healthy controls was evaluated for the estimation of urinary electrolytes. Fasting serum glucose & serum creatinine was estimated by GOD-POD & Jaffe's method respectively. Urinary electrolytes were estimated by using flame photometer.
In this study serum fasting glucose was significantly (179.85 ± 40.182 vs 73.95 ± 5.97) higher in diabetic group. Serum creatinine level was significantly (0.9125 ± 0.16 vs 1.015 ±0.17) lower in patients group when compared to control group. While in electrolytes retention of sodium occurs in diabetic group compared to other remaining electrolytes which were significantly higher in patients group.
This study suggested that diabetes mellitus is characterized by urinary electrolytes imbalance. This electrolyte imbalance can give rise to some other diseases in future.
Diabetes mellitus, hyponatriurea, hyperkaluria, hypercalciurea
