1Physiology Department, Faculty of Medicine, Thamar University, Yemen
2Physiology Department, Faculty of Medicine, Zagazig University, Egypt
3Histology Department, Faculty of Medicine, Banha University, Egypt
Online published on 19 June, 2015.
Induction of HO_1 may act as a defensive mechanism to reduce inflammation and tissue injury in the gastrointestinal tract.
can we use hemin (HO-1 inducer) as a new therapy in treatment of gastric ulcer?
48 male albino rats were divided into 6 groups. Group 1 (control): received 0.5 ml of the vehicle. Group 2: Hemin-treated group (H) received hemin one hour before the administration of Indomethacin (IND) (25 mg/kg b.w). Group 3: pre-treated with famotidine (3 mg/kg). Group 4: pre-treated with 20mg/kg of omeprazole. Group 5: pretreated with famotidine and hemin. Group 6: pretreated with omeprazole and hemin.
Hemin produced a significant protective effect on gastric ulcer when used alone and highly significant changes when used with famotidine or omeprazole.
hemin can be used as a new therapy in treating gastric ulcer.
Hemin, bilirubin, heme oxygenase, indomethacin, gastric ulcer
