1Senior Resident, Department of Physiology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi
2Associate Professor, Department of Physiology, V.S.S. Medical College, Burla
Online published on 11 February, 2016.
True prevalence of diabetic neuropathy is not known, as it can develop even before the onset of clinically diagnosable diabetes mellitus because some individual may possess genetic attributes that affect predisposition to develop such complications. Nerve conduction changes are among the earliest evidence of DPN and are therefore a biomarker for subclinical neuropathy15. Due to their objective and quantitative character, they also are the most useful parameters for evaluating disease progression3.
Thirty healthy medical students as control and thirty non diabetic medical students having first degree diabetic relatives as test undergone included and excluded by doing FBS and OGTT. These groups were subjected to Median MNCV, Median SNCV and Common peroneal MNCV test. The data included in analysis are Amplitude and Conduction Velocity.
The amplitude of Median Motor (Right hand/Left hand) students having family history diabetes was found to 8.86 ± (6.20) mV/8.54 ± (5.70) mV although its normal but its significantly low than healthy students 18.13 ± (7.95) mV/16.92 ± (18.04) mV respectively. Similarly amplitude of Common Peroneal Nerve (Right Leg/Left Leg) 3.61 ± (2.20) mV/3.42 ± (2.77) mV which is less than normal range. The CV of Median Nerve right hand found to be 58 m/s which is above normal range but less than the healthy subjects. Whereas CV of Common Peroneal Nerve found to be within normal limits in both the cases.
Now it's evident that neuropathy can occur with impaired glucose tolerance and with metabolic syndrome in the absence of hyperglycemia37, 38.
CV, Conduction Velocity, DPN, Diabetic Peripheral Neuropathy, DN, Diabetic Neuropathy, NCS, Nerve Conduction Study, MNCV, Motor Nerve Conduction Velocity, SNCV, Sensory Nerve Conduction Velocity
