Pre-pondarance of Duodenal Ulcers in O Blood Group Individuals

There is relationship between ABO blood group distribution and Peptic ulcer Disease. This study sought to determine the preponderance of O blood group in patients with peptic ulcer disease in Kamineni Institute of medical Sciences, Nalgonda. Ninety patients with Peptic ulcer disease (56 male and 34 female; mean age: 50±18 years) who aended our endoscopy section were enrolled. Blood samples were used for ABO/Rhesus (Rh) blood group antigen typing. The ABO blood group phenotype distribution in subjects was as follows: 44.4% (40/90) for group A, 32.2% (29/90) for group B, 42.2%(38/90) for group O and 16.66% (15/90) for group AB. Rh positivity was found in 66.6% (60/90) of patients. In local healthy population, ABO/Rh blood group distribution was 33.8, 20.7, 34.7, 20.4 and 92.6% for A, B, 0, AB and Rh, respectively. AB blood group distribution in healthy population was higher than peptic ulcer disease (20.4 vs 16.6%). In contrast, Rh positivity of Peptic Ulcer Disease is lower than healthy subjects (66.6 vs 92.6%). Variation in the results of studies is related to different study communities. According to these results, probably ABO/Rh blood group has an important role in patients with peptic ulceration. The functional significance of ABO blood group distribution might be associated with biological behavior of Peptic Ulcer Disease. The impact of blood group on Peptic Ulcer Disease may be a focus for further studies.