International Journal of Physiology
  • Year: 2017
  • Volume: 5
  • Issue: 1

Influence of ABO Blood Groups on Activated Partial Thromboplastin Time

1Senior Resident, Department of Physiology, Osmania Medical College, Hyderabad

2Professor and Head of Department, Department of Physiology, Osmania Medical College, Hyderabad

Online published on 13 February, 2017.

Abstract

1. To determine the Activated partial thromboplastin time in O blood group individuals and in non-O blood group individuals.

2. To compare the difference in APTT between O and non-O blood group individuals.

60 healthy volunteers in the age group of 18–20 years were chosen for the study such that 30 of them belonged to O blood group and 30 belonged to non-O blood groups.

Blood grouping was done by ‘rapid slide method’ and APTT was determined by manual method following the standard procedure.

The data obtained was subjected to statistical analysis using the ‘T test.’

Statistically significant difference (p<0.05) was found in the APTT values between O and non-O blood groups with a higher mean value in O blood group compared to non-O blood group. This may be due to the lower levels of FVIII in O blood group compared to non-O blood groups. Therefore, it is concluded that the procoagulant tendency seems to be more in non-O blood groups which is reflected by the lower APTT values found in them.

Keywords

ABO Blood Groups, Activated Partial Thromboplastin Time (APTT), Coronary Artery Disease (CAD), Cardiovascular Disease (CVD), Factor VIII (FVIII), Venous Thromboembolism (VTE), Von Willebrand Factor (VWF)