Prediction of Insulin Resistance with Anthropometric Measures in Adolescence

In regions of higher incidence of diabetes, more frequent screening is recommended to improve diabetes management and to initiate prevention strategies. Some developed countries screen Obese children with higher BMI with oral glucose tolerance test each year. There is a need to validate use of anthropometric measures for screening and early detection of subjects who are at risk of developing diabetes. We hypothesized that normoglycemic young adult who are siblings of diabetics or obese subjects are genetically predisposed & they are known to have a higher substantial heritable component of insulin resistance than the siblings of non-diabetics. This study evaluated simple anthropometric measures that will be optimally required to predict insulin resistance in normoglycemic. Siblings of Diabetics were obese compared to siblings of non diabetics. Siblings of diabetics had higher BMI and Waist circumference with significantly lower IS values & higher IR values. It was observed that ISI _0–120 indices showed a significantly better correlation with compared to HOMA IR in siblings of diabetics in both first & second degree relatives. ISI_0–120 values were significantly lower in Siblings of Diabetics with higher BMI, longer Waist circumference. Significant correlation with clinical measures like BMI & waist circumference was observed. BMI <23.9 there were 50 subjects and in Group B: BMI > 24 there were 30 subjects.