1Associate Professor, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
2Assistant Professor, Department of Physiology, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
3Associate Professor, Department of Internal Medicine, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
4Assistant Professor, Department of Radiology, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
5Associate Professor, Department of Community Medicine, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
6Professor, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
7Professor & Head, Department of Physiology, SRM Medical College, Hospital & Research Centre, Potheri, Kattankulathur, India
*Corresponding author: Dr. Kanimozhi Sadasivam, MD, Associate Professor, Department of Physiology, SRM Medical College, Hospital & Research Institute, Potheri, Kattankulathur, Chennai-603203, Tamilnadu, Phone: +91-9500061772, Email: dr_kani2002@yahoo.co.in
Online published on 18 July, 2017.
Type 2 diabetes mellitus (T2DM) is a leading cause of morbidity and mortality, particularly from cardiovascular diseases. Family history of diabetes appears to increase the risk of coronary artery disease (CAD), even in non-diabetic subjects. They are insulin resistant and carry a risk of premature atherosclerosis, the extent of which can be estimated by measuring the carotid artery intima media thickness (CIMT).
To compare the CIMT in offsprings with (FH+) of T2DM and offsprings without (FH−) of T2DM. Subjects in both groups are apparently healthy individuals with no known cardiovascular risk factors.
We studied 69 young (18–25 years), adult offsprings with (FH+) of T2DM and 50 control subjects without (FH−) of T2DM (age, sex, BMI and blood pressure matched). A FH+ of T2DM was defined as having one or both parents with type 2 diabetes. All subjects underwent high resolution B-mode ultrasonographic evaluation of common carotid artery intima-media thickness. Plasma glucose and lipid profile were measured after an overnight fast of 10–12 hours.
Compared to controls, subjects with FH+ had increased CIMT, (0.46 mm ± 0.01 Vs 0.56 mm ± 0.01, P<0·001). Metabolic parameters were within normal limits and there was no statistical difference among both groups. Pearson's correlation established a significant and stronger association between CIMT and metabolic variables (fasting blood glucose, triglycerides and very low density lipoprotein cholesterol) only among FH+ subjects.
These results suggest that a genetic predisposition to T2DM may accelerate the development of atherosclerosis and increase the risk for CHD.
Type 2 diabetes mellitus, coronary heart disease, carotid artery intima media thickness, blood glucose
