1Assistant Professor, Department of Physiology, The Oxford Medical College, Hospital and Research centre, Yadavanahalli, Attibele Hobli, Anekal, Bangalore
2Professor and HOD, Department of Physiology, Bangalore Medical College and Research Institute, Fort, K R road, Bangalore
*Coresponding author: Dr Chaitra M S Assistant Professor, Department of Physiology, The Oxford Medical College, Hospital and Research centre, Yadavanahalli, Attibele Hobli, Anekal, Bangalore, E-Mail Id: chaitra.msridhar@gmail.com
Online published on 2 November, 2018.
Diabetes is one of the major causes of premature illness and death worldwide. Limitation in exercise capacity is a strong predictor of cardiovascular dysfunction and all other causes of mortality in diabetics. Since the urban population in India is more prone to Diabetes, as part of this study, an attempt is made to evaluate cardiovascular response to submaximal exercise in type 2 diabetics using Ergospirometer. Hypothesis tested is, Type2 Diabetes mellitus reduces exercise tolerance.
To record and compare the cardiovascular response to submaximal exercise in Type2 diabetics as well as healthy controls, using ergospirometer.
To compare the exercise response with respect to duration of diabetes.
The diagnosed cases of type 2 diabetes at department of Medicine, Victoria hospital, Bangalore in the age group of 35-50yrs were taken up for the study. Subjects were asked to perform submaximal exercise on MEC PFT system till heart rate reaches 70% of maximal (220-age bpm). Their cardiovascular responses as reflected in the parameters (heart rate, blood pressure and oxygen pulse) were recorded.
Results showed that resting systolic (p=<0.01) and diastolic blood pressure (p=<0.01) is high in diabetics. Abnormal cardiovascular response to submaximal exercise was seen in diabetics with significant rise in systolic BP (p=<0.01) and diastolic BP (p=<0.01). Exercise intolerance is increasing with the duration of diabetes, which is shown by significant increase in HR (p=0.06), SBP (p=0.04) and reduction in oxygen pulse (p=<0.01). Findings of our study prove our hypothesis that there is exercise intolerance in type 2 diabetics even without clinical cardiovascular disease. It also shows that exercise intolerance is progressive with duration of disease. Underlying pathophysiology is multifactorial and involves alterations in ventricular-vascular coupling consisting of cardiac changes and pulmonary changes due to disease which influence integrity of pulmonary connective tissue and microvasculature.
Type 2 Diabetes, Cardiovascular responses, Ergospirometer, submaximal exercise
