International Journal of Physiology

Histocompatibility testing of HLA-A, HLA-B and HLA-DRB1 antigens has great importance in the selection of kidney recipient candidates and donors for transplantation. DNA typing of HLA Loci HLA-A, B and DRB1 loci was performed using the SSO typing kit (Luminex) for 2000 renal transplant recipients and donor who presented to our tertiary care centre. There was male preponderance among recipients and female preponderance among donors. The antigen frequency of HLA A*33: 01, B*44: 03, B*15: 18, B*57: 03 were significantly higher in donors suggesting that these antigens may have protective influence on the kidney, while antigen frequency of B*57: 01was significantly higher in recipients. Two locus haplotypes of HLA A-B, A-DRB1, B-DRB1 documented among recipients was A*24: 02, B*51: 01, A*01: 01-B*52: 01, A*68: 01-DRB1*14: 01, B*49: 01-DRB1*13: 02 and among donors was A*68: 01-DRB1*13: 01, A*03: 01B*35: 01, B*44: 03-DRB1*15: 02, B*13: 01-DRB1*07: 01. Three locus HLA A-B-DRB1 haplotypes documented among recipients were A*24: 02-B*40: 06-DRB1*15: 01 and A*01: 01-B*57: 01-DRB1*07: 01, suggesting that these antigens may be risk factor for renal failure. Two locus and three locus haplotypes reported in our study are not reported from other parts of India. The HLA antigens and haplotypes reported in our study will help in understanding the Indian population genetics and help the organ transplant team to find suitable matched donors for transplant recipients.