International Journal of Physiology

  • Year: 2019
  • Volume: 7
  • Issue: 3

Study of Inflammatory Biomarker (PARC/CCL 18) in Chronic Obstructive Pulmonary Disease and its Correlation with Disease Severity in South Indian Population

1Assistant Professor, Department of Physiology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil nadu, India

2Assistant Professor, Department of Physiology, JIPMER, Pondicherry, India

3Associate Professor, Department of Physiology, JIPMER, Pondicherry, India

4Professor & Head, Department of Physiology, JIPMER, Pondicherry, India

*Corresponding Author: Dr. Varadharaju, Assistant Professor, JIPMER, Karaikal, India Email Id: drvaradhu@gmail.com, Contact Mobile Number: 09884873324

Online published on 25 July, 2019.

Abstract

Our recent studies have shown that inflammatory biomarker (PARC/CCL 18) in chronic pulmonary disease and its correlation with disease severity in south Indian population. Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by chronic obstruction of lung airways which is not entirely reversible. Pulmonary and activation-regulated chemokine ligand-18(PARC/CCL18) is a 7-kD protein that is constitutively expressed by monocytes/macrophages and dendritic cells and is secreted predominantly in the lung. It is a promising inflammatory marker in COPD.

This was a Descriptive study conducted in 130 male COPD patients. It was designed to assess the specific inflammatory marker and study their relationship with disease severity levels in male COPD patients.

inflammatory biomarkers of Pulmonary and activation regulated chemokine ligand-18 levels were significantly (P<0.003) increased in very severe COPD patients when compared with mild, moderate and severe COPD patients.

From the present study, we conclude that in COPD specific biomarker serum PARC/CCL18 associated with disease severity

Keywords

Chronic obstructive pulmonary disease, Pulmonary and activation regulated chemokine ligand-18, lung