1Assistant Professor, Dept of Physiology, Chengalpattu Medical College, Chennai, India
2Professor (Senior Scale), Department of Physiology, JIPMER, Puducherry, India
3Professor and Head, Department of Physiology, JIPMER, Puducherry, India
Diet is one of the risk factors for obesity and VMH plays a substantial role in food intake and obesity. Food intake and body weight differ preferentially with gender. Insulin resistance, thyroid, and lipid profile are intimately linked to body metabolism. Thus, this study was conducted to assess the role of VMH on metabolism
The study was conducted in the Dept. of Physiology, JIPMER after ethics committee approval. The animals were fed on HFD (total of 12 female albino Wistar rats) for a period of 10 weeks. After obtaining a basal recording of food intake, body weight, glucose, insulin, thyroid, and lipid profile for a period of 1 week, animals were divided into control and experimental subgroups (each 6 female). Experimental rats underwent electrolytic ablation of VMH whereas control rats underwent sham lesion. Then a post-lesion recording was taken for four weeks and compared between groups with appropriate statistics.
VMH lesion increased food intake, body weight, blood glucose, insulin, and insulin resistance in the experimental group. VMH lesion didn't have much influence on lipid profile and thyroid profile.
VMH has a significant role in feeding behavior, adiposity genesis, insulin-glucose homeostasis, and lipid metabolism.
High-fat diet, ventromedial hypothalamus, obese rat
