International Journal of Pharmaceutical Chemistry and Analysis
  • Year: 2015
  • Volume: 2
  • Issue: 3

Synthesis of some nuclear substitution derivatives of 4-acetyl pyridine

  • Author:
  • Joohee Pradhan1,2,, Anju Goyal3
  • Total Page Count: 7
  • Page Number: 113 to 119

1Dept. of Pharmaceutical sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India-313001

2Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Pacific Hills, Udaipur, Rajasthan, India-313001

3B.N Institute of Pharmaceutical sciences, Sewashram Road, Udaipur, Rajasthan, India-313001

*Corresponding Author: E-mail: juhipradhan123@gmail.com

Online published on 28 July, 2016.

Abstract

Five nuclear substitution derivatives of 4-acetyl pyridine (2a to 6a) were prepared via N-oxidation followed by either nitration or arylation in the yield of 60–80%. Substitution at 2-position is promoted due to the electron withdrawing and meta-directing ability of acetyl group at 4-position making the pyridine N-oxide vulnerable to attack at C-2.

Keywords

4-acetyl pyridine, N-oxidation, nitration, arylation, nuclear substitution