1Assistant Professor, Department of Pharmacognosy, R.C. Patel Institute of pharmaceutical Education and Research, Shirpur, Dist. Dhule-425405
2Assistant Professor, Department of Pharmaceutical Chemistry, Shri. D. D. Vispute College of Pharmacy & Research Center, Devad-Vichumbe, Near New Panvel
*Corresponding Author: E-mail: monika.jadhav@yahoo.co.in
Online published on 28 July, 2016.
The objective of present study is to find free radical scavenging and anti-inflammatory activity of methanolic flowers and roots extracts of Cassia auriculata Linn.
The methanolic flowers and roots extracts of Cassia auriculata Linn. were investigated for their antioxidant potential and anti-inflammatory activity by using carrageenan-induced acute inflammation and cotton pellet-induced sub-chronic inflammation in rats.
The methanolic flowers extract of Cassia auriculata exhibited significant antioxidant and anti-inflammatory activity by reducing carrageenan and cotton pellet induced change in bio-chemical parameters. The methanolic flowers extract showed 54.20% and 55.76% while methanolic roots extract showed 52.52% and 53.84% inhibition in carrageenan-induced, cotton pellet-induced inflammation in rats respectively. Both the extracts of flowers and roots were tested for the presence of phytochemical constituents and studies confirmed the presence of the active phytoconstituents in methanolic extract of flowers, which may interfere with free-radical formation and accounts for the significant anti-inflammatory activity.
The present study indicates the medicinal value of Cassia auriculata in the management of inflammation.
Cassia auriculata, Antioxidant, anti-inflammatory, Carageenan, cotton pellet
