Synthesis and Antimicrobial Activity of Novel 5-Arylidene-3-(2-phenyl 4-oxo-1, 3-thiazolidine) succinimido aceto hydrazide Derivatives

Ethyl N-Succinimido acetate was synthesized by equimolar condensation of succinimide and ethylchloroacetate by refluxing in presence of anhydrous potassium carbonate. Then Ethyl N-succinimido acetate was refluxed with hydrazine hydrate in presense of 1, 4-dioxane to obtain N-Succinimido acetylhydrazide, which was further treated with benzaldehyde to get phenyl succinimido acetylhydrazide, this compound was cyclized with mercaptoacetic acid to get the 3-(2-phenyl 4-oxo-1, 3-thiazolidine) acetamido succinimide which was reacted with various aldehyde to get the 5-Arylidene-3-(2-phenyl 4-oxo-1, 3-thiazolidine) succinimido aceto hydrazide. The formation of title compounds confirmed by physical and spectral data. The synthesized compounds were subjected to microbiological screening.