International Journal of Pharmaceutical Chemistry and Analysis
  • Year: 2016
  • Volume: 3
  • Issue: 2

Pharmacokinetic evaluation of ritonavir crystallo co-agglomerates in rat module

1Professor, Dept. of Quality Assurance, AISSMS College of Pharmacy, Maharashtra

2Research Student, Dept. of Quality Assurance, AISSMS College of Pharmacy, Maharashtra

3Associate Professor, Dept. of Pharmacology, AISSMS College of Pharmacy, Maharashtra

*Corresponding Author: Email: santoshvgandhi@rediffmail.com

Online published on 19 September, 2016.

Abstract

The present work was done to evaluate pharmacokinetic parameters of ritonavir standard, ritonavir crystallo co agglomerates and marketed formulation of ritonavir. The aim of formulation of Ritonavir crystallo co agglomerates was immediate drug release and solubility enhancement. The analysis was carried out by HPLC. The parameters evaluated were Cmax, Tmax, area under curve (AUC 0-t, AUC 0-∞), t1/2, k elimination (ke).

Keywords

Ritonavir, Pharmacokinetic study, HPLC, Crystallo co agglomerates