1Dept. of Pharmacy, Banasthali University, Tonk, Rajasthan
2Dept. of Bioinformatics Infrastructure Facility, Jamia Hamdard, New Delhi
3Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi
*Corresponding Author: Email: mymoonaakhter@gmail.com
Online published on 4 November, 2016.
The present investigation was undertaken to understand the overlaying problems of mutation in HIV virus leading to failure to combat AIDS.
In present study Multiple Linear Regression (MLR) analysis was carried on a series of 71(sulfonyl) benzene analogs reported as viral nucleocapsid protein zinc finger modulators for HIV.
The MLR model obtained using carbo method (N*N) similarity showing good predictive ability, r2 (training) = 0.655, r2(test) = 0.605.
The results indicated that Refractivity Similarity (polarizability and volume) and Shape Similarity are important parameters in predicting the activity of viral nucleocapsid protein zinc finger inhibitors.
Refractivity Similarity, Shape Simliarity, Carbo, MLR, Viral Nucleocapsid Protein Zinc Finger, HIV
