SEM based comparative study of diluted pharmaceutical agents silica and potassium chloride

The morphological changes occurring because of trituration and solid dilution have been assessed by surface electron microscopy to follow medicinally active ingredients and validation of these findings became the objective of the study. Diluted Pharmaceutical agents Silica and Potassium Chloride were analyzed for comparison. The SEM presentation of the biochemic drugs support the idea that it is the unique characteristic change of the virgin drug substances produced because of trituration and solid dilution which is responsible for the changes in medicinal properties. The high intensity electron beam caused multiple fractures on softer molecules which helps distinguishing between lactose and the drug particles.