International Journal of Pharmaceutical Chemistry and Analysis
  • Year: 2018
  • Volume: 5
  • Issue: 1

Comparative study of olanzapine and risperidone in the control of positive and negative symptoms in the treatment of schizophrenia

  • Author:
  • Supriya Sharma1,, Yeshwant Deshmukh2, Priya Ann Sam3, Urmila Salve3
  • Total Page Count: 5
  • Page Number: 7 to 11

1PG Resident, Dept. of Pharmacology, MGM Medical College, Navi Mumbai, Maharashtra, India

2Professor, Dept. of Pharmacology, MGM Medical College, Navi Mumbai, Maharashtra, India

3PG Resident, Dept. of Pharmacology, MGM Medical College, Navi Mumbai, Maharashtra, India

*Corresponding Author: Email: bhanusharma1995@rediffmail.com

Online published on 27 November, 2018.

Abstract

To compare the efficacy of olanzapine and risperidone in the treatment of positive and negative symptoms of schizophrenia.

The study was conducted in MGM medical college Navi Mumbai between October 2012 to September 2014. The study included 110 patients of schizophrenia. The positive and negative symptoms were assessed with the help of the PANSS (positive & negative symptom score) scale.

We observed that the mean percentage reduction in score in the positive scale of PANSS was 48.74% in the risperidone and 49.40% in the olanzapine group. The negative score reduced by 56.32% in the Risperidone group and by 61.59% in the olanzapine group on the PANSS.

olanzapine was superior to risperidone in controlling the positive as well as negative symptoms of schizophrenia clinically but the results were not statistically significant.

Keywords

Olanzaine, Risperidone, Schizophrenia