1Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., India.
2Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., India.
3Department of Obstetrics & Gynaecology, Saraswathi Institute of Medical Sciences Hapur, Ghaziabad, U.P., India.
Patient with epilepsy may manifest metabolic adverse effect through the course of their management with antiepileptic drugs. One hundred and twenty patients with epilepsy both male and female who had been on various anticonvulsant drugs were selected for the study of their lipid profile. The study showed a significant increase serum level of triglyceride, total cholesterol, HDLc and VLDLc in patients receiving combination therapy of either Phenytoin and Phenobarbitone or Phenytoin and Carbamazepine or Phenytoin alone. Patients receiving Carbamazepine alone had significant increase in serum levels of triglyceride and VLDLc but no significant changes in serum levels of total cholesterol & HDLc in this group. A significant correlation between duration of anticonvulsant therapy and lipid profile was established. The results showed adverse effect on cholesterol levels in patients on long term antiepileptic drugs therapy. It is recommended lipid profile should be regularly checked in patients undergoing such treatment.
Anticonvulsant drugs, Epilepsy, Lipid profile, metabolic abnormalities, Seizure
