1Department, Dept. of Biochemstry,.
2Department of Biochemistry, Pt JNM Medical College Raipur, Chhattisgarh.
3Department of Biochemistry, Saraswati Institute of Medical Sciences, Hapur, UP.
4Indian Red Cross Society, Branch, Raipur, Chhattisgarh.
Sickle cell disease (SCD) is the commonest abnormal hemoglobin in the world. The present study evaluated the SCD in state of Chhattisgarh. The study was conducted in Center for Genetic Diseases & Molecular Biology, Department of Biochemistry, Pt JNM Medical College & associated BRA Hospital, Raipur during the period of 4 years from May 2003 to April 2007. The screening was conducted on a total of 38472 individuals. We found that the prevalence of SCD in India is highest in the state of Chhattisgarh (23%). Though the prevalence is high for tribal and scheduled caste populations, the prevalence is highest for Kurmi (55%)and Teli (53%)caste which belong to backward castes. Solubility tests are highly sensitive and specific for detecting SCD & can easily be used for mass screening of SCD.
The term SCD in the present study includes both sickle cell trait and homozygous sickle cell anemia.
