1Karbala University, College of Medicine, Anatomy and Embryology Department Iraq
2Urology and Infertility Department Kufa University, College of Medicine, Iraq
3Al-Zahraa Obstetrics, Gynaecology and Paediatric Hospital in Al-Najaf Governorate, Iraq
*Corresponding Author: Rihab Abbas Ali Karbala University, College of Medicine, Anatomy and Embryology Department, Iraq, Email: rihababbas89@yahoo.com, zaaj.2010@gmail.com
Online published on 21 February, 2019.
Cytokines have an important and controversial role during ovarian folliculogenesis for the development of fertilizable and mature oocytes. Many cytokines are essential for reproductive processes and their role in the female reproductive system function widely investigated during controlled ovarian stimulation as part of IVF attempts.
to evaluate the effect of serum and follicular fluid IL-1beta on ICSI outcome.
the study included 45 infertile, COH with short protocol done to them. E2, FSH, LH on the second day of cycle and E2 at the day of HCG injection measured. Serum and follicular IL-1beta measured at the day of oocyte retrieval.
Serum IL-1beta negatively correlated with the fertilisation rate, cleavage rate, and no. of embryo transferred (P-value < 0.05). There is no significant correlation between follicular IL-1beta and ICSI outcome.
Serum IL-1beta can serve as a negative predictor for ICSI outcome.
IL-1beta, IVF, ICSI, controlled ovarian stimulation, COH
