Indian Journal of Public Health Research & Development
  • Year: 2019
  • Volume: 10
  • Issue: 10

Seroprevalence Rates of Typhoid Fever among Children in Endemic Areas, South Sulawesi, Indonesia

  • Author:
  • Ressy Dwiyanti1,2, Mochammad Hatta2,, Rosdiana Natzir3, Sutji Pratiwi3, Muhammad Sabir1,2, Yadi Yasir2,4, Rizki, Amelia Noviyanthi2
  • Total Page Count: 5
  • Page Number: 1130 to 1134

1Department of Medical Microbiology, Faculty of Medicine, Tadulako University, Palu

2Molecular Biology and Immunology Laboratory for Infectious Diseases, Department of Medical Microbiology, Faculty of Medicine, Hasanuddin University, Makassar

3Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar

4Department of Microbiology and Immunology, Faculty of Medicine, Mulawarman University, Samarinda, Indonesia

*Corresponding Author: Prof. Mochammad Hatta, MD, PhD., Molecular Biology and Immunology Laboratory for Infectious Diseases, Department of Medical Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, e-mail: hattaram@yahoo.co

Online published on 23 December, 2019.

Abstract

Typhoid fever is still a major health problem in endemic countries. However, the real magnitude of the incidence rate is unclear and difficult to determine. This study is to evaluate the validity of extrapolation of the seroprevalence in children as a proxy indicator for the level of endemicity.

Two rural areas of South Sulawesi (Paitana subdistrict as the high-endemic area and Bantimurung subdistrict as low-endemic), Indonesia with approximately 1, 000 inhabitants each were selected for this study. Diagnosis of typhoid fever was based on the clinical signs and Widal test confirmed by blood culture. Sera were taken from subjects for determination of IgM by ELISA.

The incidence rate of typhoid fever among community both in Paitana and Bantimurung subdistrict was 20.60/1, 000 and 8.5/1, 000 population, respectively; while the incidence rate of typhoid fever among children both in Paitana and Bantimurung subdistrict was 35.83/1, 000 and 9.30/1, 000 children, respectively. The seropositivity rates of community in Paitana were significant higher than in Bantimurung subdistrict (11.42% vs 4.67%) (p <0.05). Also, the seropositivity rates of children in Paitana were significantly higher than in Bantimurung subdistrict (45.60% vs. 11.63%) (p<0.05). The high-endemic area in Paitana had similar high-incidence and seroprevalence rates both in community and children. In contrast, Bantimurung subdistrict had much lower incidence and seroprevalence rates both in community and children. The correlation coefficient between incidence and seroprevalence rates was 0.98.

The results revealed that seroprevalence rates among children may use as an indicator and extrapolation of typhoid fever endemicity.

Keywords

Typhoid fever, seroprevalence, community, children, Indonesia