Department of Biochemistry, College of Medicine, Aliraqia University, Baghdad, Iraq
Polycystic ovarian syndrome (PCOS) is a common heterogeneous, multifactorial and chronic endocrine disorder characterized by multiple hormonal imbalances, occupied by manifestations of hyperandrogenism and many a times with hyperthyroidism. Clomiphene is a well known drug for its safety, effectiveness and relatively low cost as compared to other drugs. The aim of the present study is to evaluate the effect of clomiphene on anthropometry measurement and thyroxine hormones in Iraqi women. Seventy three infertile patients with polycystic ovary syndrome (PCOS) were enrolled in the present study. They were randomly divided into three groups. Three doses of clomiphine (50, 100 and 150mg) were given to enrolled patients (n=72). Lower concentration of clomiphene showed decreases in the body mass index and waist-hip ratio of obese and overweight individuals. Lower dose (50mg) of the clomiphene is effective while higher dose (100 and 150mg) showed non-significant increase in the serum T3 level. The present study concluded that clomiphene act effectively on the obesity and patients treated with this showed a positive effect.
Polycystic ovarian syndrome, hyperthyroidism, thyroid hormones, T3 and T4 levels
